Peer-Reviewed Publications

 

  1. Ortega-Rivera. O.; Pokorski, J.K.; Steinmetz, N.F. "A single-dose, implant-based, trivalent virus-like particle vaccine against “cholesterol checkpoint” proteins", In Press at Advanced Therapeutics

  2. Schara, S.; Lau, R.; Church, D.C.; Pokorski, J.K.; Lipomi, D.J. "Polymer Chemistry for Haptics, Soft Robotics, and Human-Machine Interfaces", In Press at Advanced Functional Materials

  3. Zheng, Y.; Pokorski, J.K.* "Hot Melt Extrusion: An emerging manufacturing method for slow and sustained protein delivery", WIRES Nanomedicine and Nanobiotechnology, 2021, e1712

  4. Shao, S.; Ortega-Rivera, O.A.; Pokorski, J.K.*; Steinmetz, N.F.* “A Scalable Manufacturing Approach to Single-dose Vaccination Against HPV”, Vaccines, 2021, 9, 66.

  5. Schinazi, G.; d’Amleida, J.R.; Pokorski, J.K.; Schiraldi, D.A. "Bio-Based Flame Retardation of Acrylonitrile-Butadiene-Styrene", ACS Applied Polymeric Materials, 2021, 3, 372-388.

  6. Lu, C.; Church, D.C.; Learn, G.D.; Pokorski, J.K.; von Recum, H.A. “Modified Cyclodextrin Microparticles to Improve PMMA Drug Delivery Without Mechanical Loss”, Macromolecular Bioscience, 2021, In Press

  7. Miller, E.P.; Pokorski, J.K.; Palomo, L.V.; Eppell, S.J.* “A Bottom-up Approach Grafts Collagen Fibrils Perpendicularly to Titanium Surfaces.”, ACS Applied Biomaterials, 2020, 3, 6088-6095.

  8. Shin, M.; Shukla, S.; Chung, Y.H.; Beiss, V.; Chan, S.K.; Ortega-Rivera, O.; Wirth, D.M.; Chen, A.; Sack, M.; Pokorski, J.K.; Steinmetz, N.F. ““COVID-19 vaccine development and a potential nanomaterial path forward”, Nature Nanotechnology, 2020, 15, 646-655.

  9. Church, D.C.; Takiguchi, L.; Pokorski, J.K.* "Optimization of Ring-Opening Metathesis Polymerization (ROMP) under Physiologically Relevant Conditions", Polymer Chemistry, 2020, 11, 4492-4499.

  10. Van de Voorde, K.M.; Pokorski, J.K.*; Korley, L.T.J.* “Exploring morphological effects on the mechanics of blended PLA/PCL extruded fibers fabricated using multilayer coextrusion”, Macromolecules, 2020, 13, 5047-5055.

  11. Church, D.C.; Pokorski, J.K.* “Cell Engineering with Functional Poly(oxanorbornene) Block Copolymers”, Angewandte Chemie, 2020, 59, 11379-11383.

  12. Wirth, D.M.; Jaquez, A.; Gandarilla, S.; Hochberg, J.D.; Church, D.C.; Pokorski, J.K.* “A Highly Expandable Foam for Lithographic 3D Printing”, ACS Applied Materials and Interfaces, 2020, 12, 19033-19043.

  13. Lopez, M.A.; Soto, R.F.; Wang, C.; Rueda, R.; Shukla, S.; Silva‐Lopez, C.;  Kupor, D.;  McBride, D.A.;  Pokorski, J.K.;  Nourhani, A.; Steinmetz, N.F.;  Shah, N.J.;  Wang, J. "Built-in Active Microneedle Patch with Enhanced Autonomous Drug Delivery", Advanced Materials, 2020, 1905740.

  14. Wirth, D.M.; Pokorski, J.K.* “Design and Fabrication of a Low-Cost Pilot-Scale Melt-Processing System”, Polymer, 2019, 121802

  15. Pokorski, J.K.; Hore, M.J. “Structural Characterization of Protein-Polymer Conjugates for Biomedical Applications with Small-Angle Scattering”, Current Opinion in Colloid and Interface Science, 2019, 42, 157-168.

  16. Zheng, Y.; Lee, P.W.; Wang, C.; Thomas, L.D.; Stewart, P.L.; Steinmetz, N.F.*; Pokorski, J.K.* “Freeze Drying to Produce Efficacious CPMV Virus-like Particles”, Nano Letters, 2019, 19, 2099-2105.

  17. Pokorski, J.K.*, Smith, L.E. “ ‘Click’ Chemistry for Medicine and Biology”, Molecular Pharmaceutics, 2018, 15, 2891. (Editorial for special issue in honor of M.G. Finn’s 60th birthday)

  18. Purwar, M.; Pokorski, J.K.; Singh, P; Bhattacharyya, S; Arendt, H; DeStefano, J; La Branche, C.C.; Montefiori, D.C.; Finn, M.G.; Varadarajan, R. “Design, display and immunogenicity of HIV1 gp120 fragment immunogens on Qβ virus like particles”, Vaccine, 2018, 36, 6345-6353. 

  19. Hutnick, M.A.; Pokorski, J.K.* “Polymeric Interventions for Microbial Infections: A Review”, Molecular Pharmaceutics, 2018, 15, 2910–2921.

  20. Zheng, Y.; Lucius-Dougherty, M.; Konkolewicz, D.; Steinmetz, N.F.; Pokorski, J.K.* “Green Nanofillers: Plant Virus Reinforcement in Hydrophilic Polymer Composites”, Polymer, 2018, 142, 72-79.

  21. Lee, P.W.; Pokorski, J.K.* “PLGA Devices: Production and Applications for Sustained Protein Delivery”, WIRES Nanomedicine and Nanobiotechnology, 2018; e1516, DOI:10.1002/wnan.1516 (Invited Review)

  22. Wallat, J.D.; Harrison, J.K.; Pokorski, J.K. “pH Responsive Doxorubicin Delivery by Fluorous Polymers for Cancer Treatment”, Molecular Pharmaceutics, 2018, 15, 2954–2962.

  23. Czapar, A.E; Tiu, B.D.; Veliz, F.A.; Pokorski, J.K.; Steinmetz, N.F. “Slow-release formulation of cowpea mosaic virus for in situ vaccine delivery to treat ovarian cancer”, Advanced Science, 2018, DOI:10.1002/advs.201700991

  24. Lee, P.W.; Maia, J.; Pokorski, J.K.* “Milling Solid Proteins to Enhance Activity After Melt-Encapsulation”, International Journal of Pharmaceutics, 2017, 533, 254-265.

  25. Lee, P.W.; Shukla, S.; Wallat, J.D.; Danda, K.C.; Maia, J.; Steinmetz, N.F.; Pokorski, J.K.* “Virus-like Particle Laden Biodegradable Implants Prepared via Melt Processing”, ACS Nano,  2017, 11, 8777-8789.

  26. Jordan, A.M.; Kim, S.E.; Van de Voorde, K.; Pokorski, J.K.; Korley, L.T.J. "In Situ Fabrication of Fiber Reinforced Three-Dimensional Hydrogel Tissue Engineering Scaffolds", ACS Biomaterials Science and Engineering, 2017, 3, 1869-1879.

  27. Kim, S.E.; Lee, P.W.; Pokorski, J.K.* “Biologically Triggered Delivery of EGF from Polymer Fiber Patches” ACS Macro Lett., 2017, 6, 593-597.

  28. Johansen, M.; Gao, Y.; Hutnick, M.A.; Craig, S.E.L.; Pokorski, J.K.; Flask, C.A.; Brady-Kalnay, S.M. “Quantitative Molecular Imaging with a Single Gd-based Contrast Agent Reveals Specific Tumor Binding and Retention In Vivo”, Anal. Chem., 2017, 89, 5932-5939.

  29. Wallat, J.D.; Wek, K.; Chariou, P.; Carpenter, B.L.; Ghiladi, R.A.’ Steinmetz, N.F.; Pokorski, J.K.* “Fluorinated Polymer-Photosensitizer Conjugates Enable Improved Generation of ROS for Anticancer Photodynamic Therapy”, Polymer Chemistry, 2017, 8, 3195-3202.

  30. Kim, S.E.; Jordan, A.M.; Korley, L.T.J.; Pokorski, J.K.* “Drawing in poly(ε-caprolactone) fibers: tuning mechanics, fiber dimensions and surface-modification density”, J. Mat. Chem. B., 2017, 5, 4499-4506. *Highlighted in the emerging investigators themed collection

  31. Cyphert, E.; Wallat, J.D.; Pokorski, J.K.; von Recum, H.V. “Erythromycin modification thatimproves its acidic stability while optimizing it for local drug delivery”, Antibiotics, 2017, Apr 25;6(2). pii: E11. doi: 10.3390/antibiotics6020011

  32. Lee, P.W.; Isarov, S.A.; Wallat, J.D.; Molugu, S.K.; Shukla, S.; Sun, J.E.P.; Zhang, J.; Zheng, Y.; Lucius Dougherty, M.; Konkolewicz, D.; Stewart, P.L.; Steinmetz, N.F.; Hore, M.J.A.; Pokorski, J.K.* “Polymer Structure and Conformation Alter Immune Recognition of Virus-like Particle-Polymer Conjugates”, J. Am. Chem. Soc., 2017, 139, 3312-3315. * Featured as cover art and as a JACS Spotlight

  33. Hutnick, M.A.; Ahsanuddin, S.; Guan, L.; Lam, M.; Baron, E.; Pokorski, J.K.* “PEGylated Dendrimers as Drug Delivery Vehicles for Photosensitizer Silicon Phthalocyanine Pc 4 for Candidal Infections”, Biomacromolecules, 2017, 18, 379–385.

  34. Wallat, J.D.; Czapar, A.E.; Wang, C.; Wen, A.M.; Wek, K.S.; Yu, X.; Steinmetz, N.F.; Pokorski, J.K.* “Optical and Magnetic Resonance Imaging Using Fluorous Colloidal Nanoparticles”, Biomacromolecules, 2017, 18, 103-112. 

  35. Tiu, B.D.; Kernan, D.L.; Tiu, S.B.; Wen, A.M.; Zheng, Y.; Pokorski, J.K.; Advincula, R.C.; Steinmetz, N.F. “Electrostatic layer-by-layer construction of fibrous TMV biofilms for applications in medicine”, Nanoscale, 2017, 9, 1580-1590.

  36. Chen, Q.; Mangadlao, J.D.; Wallat, J.D.; De Leon, A.; Pokorski, J.K.; Advincula, R.C. “3D Printing Biocompatible Polyurethane/Poly(lactic acid)/Graphene Oxide Nanocomposites: Anisotropic Properties”, ACS Applied Materials and Interfaces, 2017, 9, 4015–4023.

  37. Rahman, M.A.; Lee, P.W.; Zhang, C.; Pokorski, J.K.; Baer, E. “Polyolefin Microfiber Based Antibacterial Fibrous Membrane by Forced Assembly Coextrusion”, Macromolecular Materials and Engineering, 2017, 302, DOI: 10.1002/mame.201600304

  38. Jordan, A.M.; Viswanath, V.; Kim, S.E.; Pokorski, J.K.; Korley, L.T.J.“Processing and surface modification of polymer nanofibers for biological scaffolds: a review”, J. Mat. Chem. B, 2016, 4, 5958-5974.

  39. Isarov, S.A.; Lee, P.W.; Towslee, J.H.; Hoffman, K.M.; Davis, R.D.; Maia, J.M.; Pokorski, J.K.* “DNA as a Flame Retardant Additive for Low-Density Polyethylene”, Polymer, 2016, 97, 504-514.

  40. Chariou, P.L.;  Lee, K.L.; Pokorski, J.K.; Saidel, G.M.; Steinmetz, N.F. “Diffusion and Uptake of Tobacco Mosaic Virus as Therapeutic Carrier in Tumor Tissue: Effect of Nanoparticle Aspect Ratio”, J. Phys Chem B, 2016, 120, 6120-6129.

  41. Kim, S.E.; Zhang, C.; Advincula, A.A.; Baer, E.; Pokorski, J.K.* “Protein and Bacterial Antifouling of Melt Coextruded Nanofiber Mats”, ACS Applied Materials and Interfaces, 2016, 8, 8928-8938.

  42. Isarov, S.A.; Lee, P.W.; Pokorski, J.K.* “‘Graft-to’ Protein:Polymer Conjugates Using Polynorbornene Block Copolymers”, Biomacromolecules, 2016, 17, 641-648.

  43. Isarov, S.A.; Pokorski, J.K.* “Protein ROMP: Aqueous Graft-from Ring-Opening Metathesis Polymerization”, ACS Macro Letters, 2015, 4, 969-973. *Highlighted as cover art

  44. Herrmann, K.; Johansen, M.; Craig, S.; Vincent, J.; Howell, M.; Gao, Y.; Lu, L.; Erokwu, B.; Agnes, R. Lu, Z-R.; Pokorski, J. K.; Basilion, J.; Gulani, V.; Griswold, M.; Flask, C.; Brady-Kalnay, S. “Molecular imaging of tumors using a quantitative T1 mapping technique”, Diagnostics, 2015, 5(3), 318-332.

  45. Lee, P.W.; Towslee, J.H.; Maia, J.; Pokorski, J.K.* “PEGylation to Improve Protein Stability During Melt Processing”, Macromolecular Bioscience, 2015, 15, 1332-1337.

  46. Kim, S.E.; Wallat, J.D.; Harker, E.C.; Advincula, A.A.; Pokorski, J.K.* “Multifunctional and Spatially Controlled Bioconjugation to Melt Coextruded Nanofibers”, Polymer Chemistry, 2015, 6, 5683-5692. (Highlighted in the Emerging Investigators Special Themed Issue)

  47. Lee, K.L.; Shukla, S.; Wu, M.; Ayat, N.R.; El Sanadi, C.E.; Wen, A.M.; Edelbrock, J.F.; Pokorski, J.K.; Commandeur, U.; Dubyak, G.R.; Steinmetz, N.F. “Stealth Filaments: polymer chain length and conformation affect the in vivo fate of PEGylated potato virus X”, Acta Biomaterialia, 2015, 19, 166-179.

  48. Kim, S.E.; Harker, E.C.; De Leon, A.C.; Advincula, R.C.; Pokorski, J.K.* “Coextruded, aligned, and gradient-modified poly(ℇ-caprolactone) fibers as platforms for neural growth”, Biomacromolecules, 2015, 16, 860-867.

  49. Kim, S.E.; Wang, J.; Jordan; A.M.; Korley, L.T.J.; Baer, E.; Pokorski, J.K.* “Surface Modification of Melt Extruded Poly(ℇ-caprolactone) Nanofibers: Toward A New Scalable Biomaterial Scaffold”, ACS Macro Letters, 2014, 3, 585-589.

  50. Wallat, J.D.; Rose, K.A.; Pokorski, J.K.* “Proteins and Substrates for Controlled Radical Polymerization”, Polymer Chemistry, 2014, 5, 1545-1558. *Highlighted as cover art

  51. von Recum, H.A.; Pokorski, J.K.* “Peptide and Protein based inhibitors of HIV Co-receptors”, Experimental Biology and Medicine, 2013, 238, 442-449.

  52. Pokorski, J.K.; Appella, D.H. “Combinatorial Synthesis, Screening, and Binding Studies of Highly Functionalized Polyamino-amido Oligomers for Binding to Folded RNA”, Journal of Nucleic Acids, 2012, vol. 2012, Article ID 971581 (Invited Article). 

  53. Wen, A.M.; Ryan, M.J.; Yang, A.C.; Breitenkamp, K.; Pokorski, J.K.; Steinmetz, N.F. “Photodynamic activity of viral nanoparticles conjugated with C60”, Chem Commun, 2012, 48, 9044-9046.

  54. Nicolaou, K.C.; Valiulin, R.A.; Pokorski, J.K.; Chang V.; Chen, J.S.; “Bio-inspired synthesis and biological evaluation of a colchicine-related compound library” Bioorg. Med. Chem. Lett., 2012, 22, 3776-3780.

  55. Pokorski, J. K.; Hovlid, M. L.; Finn, M.G. “Cell Targeting with Hybrid Qβ Virus-Like Particles Displaying Epidermal Growth Factor”, ChemBioChem, 2011, 12, 2441-2447.

  56. Pokorski, J. K.; Breitenkamp, K.; Liepold, L. O.; Qazi, S.; Finn, M.G. “Functional Virus-BasedPolymer-Protein Nanoparticles by Atom Transfer Radical Polymerization”, J. Am. Chem. Soc. 2011, 133, 9242-9245.

  57. Pokorski, J. K.; Steinmetz, N. F. “The Art of Engineering Viral Nanoparticles” Mol. Pharm. 2011, 8, 29-43.

  58. Pokorski, J. K.; Miller Jenkins, L. M.; Feng, H.; Durell, S.R.; Bai, Y.; Appella, D.H. “Introduction of a triazole amino acid into a peptoid induces turn formation in aqueous solution”, Org. Lett. 2007, 9, 2381-2383.

  59. Witschi, M. A.; Pokorski, J. K.; Appella, D. H. “Peptide nucleic acid (PNA) microarrays made with (S,S)-trans-cyclopentane-constrained peptide nucleic acids”, Methods Enzymol. 2006, 410, 189-200.

  60. Guler, M. O.; Pokorski, J. K.; Appella, D. H.; Stupp, S. I. “Enhanced oligonucleotide binding to self-assembled nanofibers”, Bioconjugate Chem. 2005, 16, 501-503.

  61. Pokorski, J.K.; Nam, J.M.; Vega, R. A.; Mirkin, C.A.; Appella, D.H. “Cyclopentane-modified PNA improves the sensitivity of nanoparticle-based scanometric DNA detection”, Chem. Commun. 2005, 16, 2101-2103.

  62. Pokorski, J.K.; Myers, M.C.; Appella, D.H. “Cyclopropane PNA: observable triple melting in a PNA constrained with a three-membered ring”, Tet. Lett. 2005, 46, 915-917.

  63. Myers, M.C.; Pokorski, J.K.; Appella, D.H. “Polyamine nucleic acids: Peptide nucleic acids with a flexible secondary amine in the backbone maintain oligonucleotide binding affinity”, Org. Lett. 2004, 6, 4699-4702.

  64. Pokorski, J.K.; Witschi, M.A.; Purnell. B.L.; Appella, D.H. “(S,S)-trans-cyclopentane-constrained peptide nucleic acids. A general backbone modification that improves binding affinity and sequence specificity”, J. Am. Chem. Soc. 2004, 126, 15067-15073.

​

Book Chapter

​

  1. Glidden, M.D., Edelbrock, J.F., Wen, A.M., Shukla, S., Ma, Y., French, R.H., Pokorski, J.K., Steinmetz, N.F., Application of engineered viral nanoparticles in materials and medicine, in Chemoselective and Bioorthogonal Ligation Reactions: Concepts and Applications, Wiley-VCH, 631-710. DOI: 10.1002/9783527683451.ch18

Jon Pokorski    |    858.246.3183    |    jpokorski@ucsd.edu